A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology

Using marijuana is your best bet for avoiding the ravages of Alzheimer's disease. And you don't have to use enough to get stoned, used as a preventative, one puff is enough to protect the brain from the inflammation and changes that lead to Alzheimer's dementia. A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology                                                       Lisa M. Eubanks,† Claude J. Rogers,† Albert E. Beuscher, IV,‡ George F. Koob,§ Arthur J. Olson,‡ Tobin J. Dickerson,† and Kim D. Janda corresponding author†

:Abstract: Alzheimer's disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer's disease are expected to triple over the next 50 years. Consequently, the development of treatments that slow or halt the disease progression have become imperative to both improve the quality of life for patients as well as reduce the health care costs attributable to Alzheimer's disease. Here, we demonstrate that the active component of marijuana, Δ9-tetrahydrocannabinol THC, competitively inhibits the enzyme acetylcholinesterase AChE as well as prevents AChE-induced amyloid β-peptide Aβ aggregation, the key pathological marker of Alzheimer's disease. Computational modeling of the THC-AChE interaction revealed that THC binds in the peripheral anionic site of AChE, the critical region involved in amyloidgenesis. Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Aβ aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.Keywords: Cannabinoids, Alzheimer's disease, Acetylcholinesterase

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