Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI

CBD a plant cannabinoid found in marijuana/cannabis is a possible, effective treatment for Kaposi sarcoma. It's been about 16 years since effective anti-viral medicines were released for AIDS patients so many of you have never seen someone covered in and disfigured by purple KS lesions but anything that offers relief should be made available, not kept on Schedule one of the Controlled Substances Act. KS is not a disease that is exclusive to AIDS patients therefore CBD might benefit those who cannot use anti-retroviral drugs. Legalize the plant for goodness sake! Genes Cancer. 2012 Jul;37-8:512-20.

.Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.   Maor Y, Yu J, Kuzontkoski PM, Dezube BJ, Zhang X, Groopman JE.  SourceDivision of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Abstract: Kaposi sarcoma is the most common neoplasm caused by Kaposi sarcoma-associated herpesvirus KSHV. It is prevalent among the elderly in the Mediterranean, inhabitants of sub-Saharan Africa, and immunocompromised individuals such as organ transplant recipients and AIDS patients. Current treatments for Kaposi sarcoma can inhibit tumor growth but are not able to eliminate KSHV from the host. When the host's immune system weakens, KSHV begins to replicate again, and active tumor growth ensues. New therapeutic approaches are needed. Cannabidiol CBD, a plant-derived cannabinoid, exhibits promising antitumor effects without inducing psychoactive side effects. CBD is emerging as a novel therapeutic for various disorders, including cancer. In this study, we investigated the effects of CBD both on the infection of endothelial cells ECs by KSHV and on the growth and apoptosis of KSHV-infected ECs, an in vitro model for the transformation of normal endothelium to Kaposi sarcoma. While CBD did not affect the efficiency with which KSHV infected ECs, it reduced proliferation and induced apoptosis in those infected by the virus. CBD inhibited the expression of KSHV viral G protein-coupled receptor vGPCR, its agonist, the chemokine growth-regulated protein α GRO-α, vascular endothelial growth factor receptor 3 VEGFR-3, and the VEGFR-3 ligand, vascular endothelial growth factor C VEGF-C. This suggests a potential mechanism by which CBD exerts its effects on KSHV-infected endothelium and supports the further examination of CBD as a novel targeted agent for the treatment of Kaposi sarcoma.

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