Cannabinoids selectively inhibit proliferation ... [J Neurooncol. 2005] - PubMed - NCBI

This is an important study because it shows that the naturally-occurring cannabinoid molecule THC was safer, and more effective against cancer cells than was a synthetic cannabinoid, WIN 55,212-2. Yet researchers are discouraged from using cannabinoids from marijuana in lieu of the synthetic ones, because good findings about THC might "send the wrong message to young people." So now young people are getting a hold of far more dangerous synthetic cannabinoids and using them recreationally...the Law of Unintended Consequences. Neurooncol. 2005 Aug;741:31-40.Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells.McAllister SD, Chan C, Taft RJ, Luu T, Abood ME, Moore DH, Aldape K, Yount G.  Abstract: Normal tissue toxicity limits the efficacy of current treatment modalities for glioblastoma multiforme GBM. We evaluated the influence of cannabinoids on cell proliferation, death, and morphology of human GBM cell lines and in primary human glial cultures, the normal cells from which GBM tumors arise. The influence of a plant derived cannabinoid agonist, Delta9-tetrahydrocannabinol Delta9-THC, and a potent synthetic cannabinoid agonist, WIN 55,212-2, were compared using time lapse microscopy. We discovered that Delta9-THC decreases cell proliferation and increases cell death of human GBM cells more rapidly than WIN 55,212-2. Delta9-THC was also more potent at inhibiting the proliferation of GBM cells compared to WIN 55,212-2. The effects of Delta9-THC and WIN 55,212-2 on the GBM cells were partially the result of cannabinoid receptor activation. The same concentration of Delta9-THC that significantly inhibits proliferation and increases death of human GBM cells has no significant impact on human primary glial cultures. Evidence of selective efficacy with WIN 55,212-2 was also observed but the selectivity was less profound, and the synthetic agonist produced a greater disruption of normal cell morphology compared to Delta9-THC.PMID: 16078104 [PubMed - indexed for MEDLINE]

via Cannabinoids selectively inhibit proliferation ... [J Neurooncol. 2005] - PubMed - NCBI.