Chemopreventive effect of the non-psychotro... [J Mol Med (Berl). 2012] - PubMed - NCBI

Chemoprevention of disease with cannabis--this is what everyone should be talking about. Using marijuana can protect you from serious illnesses by reducing inflammation, counteracting harmful oxidation, down regulating the production of harmful chemicals in the body, stimulating the production of beneficial chemicals in the body and triggering our intrinsic repair mechanisms, this is big news! We need to encourage everyone we meet to consider embracing cannabis supplementation to guard themselves from Alzheimer's disease, cancer, diabetes and more with chemoprevention.  

J Mol Med (Berl). 2012 Aug;90(8):925-34. Epub 2012 Jan 10.

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

Aviello G, Romano B, Borrelli F, Capasso R, Gallo L, Piscitelli F, Di Marzo V, Izzo AA.


Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy.


Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms.



[PubMed - in process]

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