Marijuana can relieve chemotherapy-induced pain

Another study finds that cannabinoids, like those found in marijuana, suppress the pain resulting from chemotherapy-induced neuropathy. And the Feds continue to claim that there is no medical use for marijuana. J Pain Symptom Manage. 2013 Jun 4. pii: S0885-39241300238-8. doi: 10.1016/j.jpainsymman.2013.02.018. [Epub ahead of print]A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced Neuropathic Pain.Lynch ME, Cesar-Rittenberg P, Hohmann AG.SourcePain Management Unit, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Anesthesia, Psychiatry and Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:                                  Abstract: Neuropathic pain caused by chemotherapy limits dosing and duration of potentially life-saving anti-cancer treatment and impairs quality of life. Chemotherapeutic neuropathy responds poorly to conventional treatments, and there is an urgent medical need for new treatments. Recent preclinical studies demonstrate that cannabinoid agonists suppress established chemotherapy-evoked neuropathy.OBJECTIVES:This was a pilot trial to begin to investigate a currently available cannabinoid agent, nabiximols oral mucosal spray containing cannabinoids, in the treatment of chemotherapy-induced neuropathic pain.METHODS:A randomized, placebo-controlled crossover pilot study was done in 16 patients with established chemotherapy-induced neuropathic pain. A 0-10 point numeric rating scale for pain intensity NRS-PI was used as the primary outcome measure.RESULTS:When examining the whole group, there was no statistically significant difference between the treatment and the placebo groups on the NRS-PI. A responder analysis demonstrated that there were five participants who reported a two-point or greater reduction in pain that trended toward statistical significance and the number needed to treat was five.CONCLUSION:Chemotherapy-induced neuropathic pain is particularly resistant to currently available treatments. This pilot trial found a number needed to treat of five and an average decrease of 2.6 on an 11-point NRS-PI in five "responders" as compared with a decrease of 0.6 with placebo and supports that it is worthwhile to study nabiximols in a full randomized, placebo-controlled trial of chemotherapy-induced neuropathic pain.

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