Nonpsychoactive THCA from unheated marijuana reduced nausea in lab animals more effectively than THC (from heated marijuana), legalize! How many dealers sell THCA? None. Support dispensary rights.
Br J Pharmacol. 2013 Jul 25. doi: 10.1111/bph.12316. [Epub ahead of print]
Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus.
Rock E, Kopstick R, Limebeer C, Parker L.
Department of Psychology, University of Guelph, Guelph, ON, Canada.
BACKGROUD AND PURPOSE:
We evaluated the anti-emetic and anti-nausea properties of the acid precursor of Δ9 -tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), and to determine its mechanism of action in these animal models.
We investigated the effect of THCA on lithium chloride- (LiCl) induced conditioned gaping (nausea-induced behaviour) to a flavour, and context (a model of anticipatory nausea, AN) in rats, and on LiCl-induced vomiting in Suncus murinus. Furthermore, we investigated THCA's ability to induce hypothermia and suppress locomotion [rodent tasks to assess cannabinoid1 (CB1 ) receptor agonist-like activity], and measured plasma and brain THCA and THC levels. We also determined whether THCA's effect could be blocked by pretreatment with SR141716 (SR, a CB1 receptor antagonist).
In rats, THCA (0.05 and/or 0.5 mg/kg) suppressed LiCl-induced conditioned gaping to a flavour and context; the latter effect blocked by the CB1 receptor antagonist, SR, but not by the 5-HT1A receptor antagonist, WAY100635. In S. murinus, THCA (0.05 and 0.5 mg/kg) reduced LiCl-induced vomiting; an effect that was reversed with SR. A comparatively low dose of THC (0.05 mg/kg) did not suppress conditioned gaping to a LiCl-paired flavour or context. THCA did not induce hypothermia or reduce locomotion, indicating non-CB1 agonist-like effects. THCA, but not THC was detected in plasma samples.
CONCLUSIONS AND IMPLICATIONS:
THCA potently reduced conditioned gaping in rats and vomiting in S. murinus; effects that were blocked by SR.. These data suggest that THCA may be a more potent alternative to THC in the treatment of nausea and vomiting.