THC and similar compounds suppress HIV infection and spread

Here is more evidence that using marijuana can improve the health of and increase the long-term survival of people with AIDS. THC and similar synthetic compounds block the ability of HIV to infect cells and to replicate. Recall that the Bush Sr. Administration denied medical marijuana to the numerous AIDS patients who were seeking it and ended the Compassionate Use Act rather than help the suffering. How many people died prematurely because of you old buzzard Bush? Blood drips from your mangled talons you evil vulture. Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists Servio H. Ramirez,†,1, Nancy L. Reichenbach, Shongshan Fan, Slava Rom, Steven F. Merkel, Xu Wang, Wen-zhe Ho,† and Yuri Persidsky,†,1+ Author Affiliations Department of Pathology and Laboratory Medicine and †Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, USA ↵1.Correspondence: Dept. of Pathology and Laboratory Medicine, Temple University School of Medicine, 3401 N. Broad St., Philadelphia, PA 19140, USA. E-mail: yuri.persidsky@tuhs.temple.edu or servio.ramirez@temple.edu                                                     Abstract: Infiltrating monocytes and macrophages play a crucial role in the progression of HIV-1 infection in the CNS. Previous studies showed that activation of the CB2 can attenuate inflammatory responses and affect HIV-1 infectivity in T cells and microglia. Here, we report that CB2 agonists can also act as immunomodulators on HIV-1-infected macrophages. First, our findings indicated the presence of elevated levels of CB2 expression on monocytes/macrophages in perivascular cuffs of postmortem HIV-1 encephalitic cases. In vitro analysis by FACS of primary human monocytes revealed a step-wise increase in CB2 surface expression in monocytes, MDMs, and HIV-1-infected MDMs. We next tested the notion that up-regulation of CB2 may allow for the use of synthetic CB2 agonist to limit HIV-1 infection. Two commercially available CB2 agonists, JWH133 and GP1a, and a resorcinol-based CB2 agonist, O-1966, were evaluated. Results from measurements of HIV-1 RT activity in the culture media of 7 day-infected cells showed a significant decrease in RT activity when the CB2 agonist was present. Furthermore, CB2 activation also partially inhibited the expression of HIV-1 pol. CB2 agonists did not modulate surface expression of CXCR4 or CCR5 detected by FACS. We speculate that these findings indicate that prevention of viral entry is not a central mechanism for CB2-mediated suppression in viral replication. However, CB2 may affect the HIV-1 replication machinery. Results from a single-round infection with the pseudotyped virus revealed a marked decrease in HIV-1 LTR activation by the CB2 ligands. Together, these results indicate that CB2 may offer a means to limit HIV-1 infection in macrophages.

via Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists.

Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI

CBD a plant cannabinoid found in marijuana/cannabis is a possible, effective treatment for Kaposi sarcoma. It's been about 16 years since effective anti-viral medicines were released for AIDS patients so many of you have never seen someone covered in and disfigured by purple KS lesions but anything that offers relief should be made available, not kept on Schedule one of the Controlled Substances Act. KS is not a disease that is exclusive to AIDS patients therefore CBD might benefit those who cannot use anti-retroviral drugs. Legalize the plant for goodness sake! Genes Cancer. 2012 Jul;37-8:512-20.

.Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.   Maor Y, Yu J, Kuzontkoski PM, Dezube BJ, Zhang X, Groopman JE.  SourceDivision of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Abstract: Kaposi sarcoma is the most common neoplasm caused by Kaposi sarcoma-associated herpesvirus KSHV. It is prevalent among the elderly in the Mediterranean, inhabitants of sub-Saharan Africa, and immunocompromised individuals such as organ transplant recipients and AIDS patients. Current treatments for Kaposi sarcoma can inhibit tumor growth but are not able to eliminate KSHV from the host. When the host's immune system weakens, KSHV begins to replicate again, and active tumor growth ensues. New therapeutic approaches are needed. Cannabidiol CBD, a plant-derived cannabinoid, exhibits promising antitumor effects without inducing psychoactive side effects. CBD is emerging as a novel therapeutic for various disorders, including cancer. In this study, we investigated the effects of CBD both on the infection of endothelial cells ECs by KSHV and on the growth and apoptosis of KSHV-infected ECs, an in vitro model for the transformation of normal endothelium to Kaposi sarcoma. While CBD did not affect the efficiency with which KSHV infected ECs, it reduced proliferation and induced apoptosis in those infected by the virus. CBD inhibited the expression of KSHV viral G protein-coupled receptor vGPCR, its agonist, the chemokine growth-regulated protein α GRO-α, vascular endothelial growth factor receptor 3 VEGFR-3, and the VEGFR-3 ligand, vascular endothelial growth factor C VEGF-C. This suggests a potential mechanism by which CBD exerts its effects on KSHV-infected endothelium and supports the further examination of CBD as a novel targeted agent for the treatment of Kaposi sarcoma.

via Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI.

Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI

CBD a plant cannabinoid found in marijuana/cannabis is a possible, effective treatment for Kaposi sarcoma. It's been about 16 years since effective anti-viral medicines were released for AIDS patients so many of you have never seen someone covered in and disfigured by purple KS lesions but anything that offers relief should be made available, not kept on Schedule one of the Controlled Substances Act. KS is not a disease that is exclusive to AIDS patients therefore CBD might benefit those who cannot use anti-retroviral drugs. Legalize the plant for goodness sake! Genes Cancer. 2012 Jul;37-8:512-20.

.Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.   Maor Y, Yu J, Kuzontkoski PM, Dezube BJ, Zhang X, Groopman JE.  SourceDivision of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Abstract: Kaposi sarcoma is the most common neoplasm caused by Kaposi sarcoma-associated herpesvirus KSHV. It is prevalent among the elderly in the Mediterranean, inhabitants of sub-Saharan Africa, and immunocompromised individuals such as organ transplant recipients and AIDS patients. Current treatments for Kaposi sarcoma can inhibit tumor growth but are not able to eliminate KSHV from the host. When the host's immune system weakens, KSHV begins to replicate again, and active tumor growth ensues. New therapeutic approaches are needed. Cannabidiol CBD, a plant-derived cannabinoid, exhibits promising antitumor effects without inducing psychoactive side effects. CBD is emerging as a novel therapeutic for various disorders, including cancer. In this study, we investigated the effects of CBD both on the infection of endothelial cells ECs by KSHV and on the growth and apoptosis of KSHV-infected ECs, an in vitro model for the transformation of normal endothelium to Kaposi sarcoma. While CBD did not affect the efficiency with which KSHV infected ECs, it reduced proliferation and induced apoptosis in those infected by the virus. CBD inhibited the expression of KSHV viral G protein-coupled receptor vGPCR, its agonist, the chemokine growth-regulated protein α GRO-α, vascular endothelial growth factor receptor 3 VEGFR-3, and the VEGFR-3 ligand, vascular endothelial growth factor C VEGF-C. This suggests a potential mechanism by which CBD exerts its effects on KSHV-infected endothelium and supports the further examination of CBD as a novel targeted agent for the treatment of Kaposi sarcoma.

via Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI.