Medical marijuana ingredient prevents brain damage

The words “marijuana” and “brain damage” usually go in that order in medical literature. An Israeli researcher has flipped them around, finding that THC, the active ingredient in marijuana, may arrest some forms of brain damage in mice.The loco weed already is favored by those who suffer from chronic diseases, not to mention fans of Cypress Hill, Bob Marley and the Grateful Dead.But pharmacologist Josef Sarne of Tel Aviv University found that a minuscule amount of tetrahydrocannabinol may protect the brain after injuries from seizures, toxic drug exposure or a lack of oxygen. via Medical marijuana ingredient prevents brain damage in mice -

THC from Marijuana Protects the Brain from Injury

Once again we see that using (even very small amounts of) marijuana improves our health by shielding the brain from the damage that follows a head injury. These same actions protect the brain from the age-related changes that lead to Alzheimer's disease and other forms of dementia. We need to recruit more people to use marijuana on a regular basis to lower our national health-care expenditures. Marijuana use is good for you! Tell someone today! Long-term behavioral and biochemical effects of an ultra-low dose of Δ9-tetrahydrocannabinol THC: neuroprotection and ERK signaling Miriam Fishbein, Sahar Gov, Fadi Assaf, Mikhal Gafni, Ora Keren, Yosef Sarne                                                                              Abstract: We have previously reported that a single injection of an ultra-low dose of delta-9-tetrahydrocannabinol THC; the psychoactive ingredient of marijuana protected the brain from pentylenentetrazole PTZ-induced cognitive deficits when applied 1–7 days before or 1–3 days after the insult. In the present study we expanded the protective profile of THC by showing that it protected mice from cognitive deficits that were induced by a variety of other neuronal insults, including pentobarbital-induced deep anesthesia, repeated treatment with 3,4 methylenedioxymethamphetamine MDMA; “ecstasy” and exposure to carbon monoxide. The protective effect of THC lasted for at least 7 weeks. The same ultra-low dose of THC 0.002 mg/kg, a dose that is 3–4 orders of magnitude lower than the doses that produce the known acute effects of the drug in mice induced long-lasting 7 weeks modifications of extracellular signal–regulated kinase ERK activity in the hippocampus, frontal cortex and cerebellum of the mice. The alterations in ERK activity paralleled changes in its activating enzyme MEK and its inactivating enzyme MKP-1. Furthermore, a single treatment with the low dose of THC elevated the level of pCREB phosphorylated cAMP response element–binding protein in the hippocampus and the level of BDNF brain-derived neurotrophic factor in the frontal cortex. These long-lasting effects indicate that a single treatment with an ultra-low dose of THC can modify brain plasticity and induce long-term behavioral and developmental effects in the brain.

via Long-term behavioral and biochemical effects of an ultra-low dose of Δ9-tetrahydrocannabinol THC: neuroprotection and ERK signaling - Springer.

Could Marijuana Save Professional Football?

The biggest lawsuit in sports history was filed by 2,138 former National Football League players on June 7 in federal court, charging that the NFL has “turned a blind eye to the risk” of repeated head injuries and was guilty of “mythologizing and glorifying violence through the media including its NFL Films division.” The players and their families claim that the serious health ramifications of continual blows to the head, which are integral to the sport, were hidden and that the NFL “generated false findings” to...