Cannabinoids may be therapeutic in breast c... [Oncol Nurs Forum. 2013] - PubMed - NCBI

I know it is hard for some of you to believe, but marijuana is the anti-cancer plant, science has spoken! Oncol Nurs Forum. 2013 Mar 1;402:191-2. doi: 10.1188/13.ONF.191-192

Cannabinoids may be therapeutic in breast cancer                .Behrend SW.SourceDepartment of Nursing, Fox Chase Cancer Center, Philadelphia, PA.                                                           Abstract:Cannabinoids are a group of compounds synthesized exclusively by the Cannabis sativa plant, commonly known as marijuana. In 1990, the first cannabinoid-specific membrane CB1 was characterized and cloned Matsuda, Lolait, Brownstein, Young, & Bonner, 1990, which catapulted biomedical research on these unique compounds. Cannabinoids refer to both marijuana-derived compounds with the active ingredient of 9-tetrahydrocannabinol THC and also the synthetic molecules that activate the same primary targets as THC. Therapeutic properties of marijuana have been well established; however, the clinical use of either plant-sourced or pure cannabinoids remains limited. The anticachexia properties of cannabinoids are found in tetrahydrocannabinol oral capsules of synthetically generated THC and are used to manage weight loss, wasting syndrome, and nausea and vomiting associated with cancer treatment.PMID: 23448745 [PubMed - in process]

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OnMedica - News - Alcohol major contributor to cancer deaths

Marijuana has powerful anti-cancer activity. Alcohol is a powerful cancer promoting agent. If you're going to drink, you damn well need to be toking too! Alcohol major contributor to cancer deaths

A drink a day can increase breast cancer risk by 5%2     Even light drinking raises breast cancer risk   Alcohol major contributor to cancer deaths                                                                                     15 February 2013                                Alcohol is a major contributor to cancer deaths and years of potential life lost, researchers have found.These findings, published in the American Journal of Public Health, also show that reducing alcohol consumption is an important cancer prevention strategy as alcohol is a known carcinogen even when consumed in small quantities.Previous studies consistently have shown that alcohol consumption is a significant risk factor for cancers of the mouth, throat, oesophagus and liver. More recent research has shown that alcohol also increases the risk of cancers of the colon, rectum and female breast. Estimates have shown that alcohol accounts for about 4% of all cancer-related deaths worldwide.In this new study, researchers from the Boston University School of Medicine BUSM and Boston University School of Public Health BUSPH examined recent data from the US on alcohol consumption and cancer mortality. They found that alcohol resulted in approximately 20,000 cancer deaths annually, accounting for about 3.5% of all cancer deaths in the US.Breast cancer was the most common cause of alcohol-attributable cancer deaths in women, accounting for approximately 6,000 deaths annually, or about 15% of all breast cancer deaths. Cancers of the mouth, throat and oesophagus were common causes of alcohol-attributable cancer mortality in men, resulting in a total of about 6,000 annual deaths.The researchers also found that each alcohol-related cancer death accounted for an average of 18 years of potential life lost. In addition, although higher levels of alcohol consumption led to a higher cancer risk, average consumption of 1.5 drinks per day or less accounted for 30% of all alcohol-attributable cancer deaths."The relationship between alcohol and cancer is strong, but is not widely appreciated by the public and remains underemphasised even by physicians," said senior author Timothy Naimi from the Department of Medicine at BUSM."Alcohol is a big preventable cancer risk factor that has been hiding in plain sight," he added.

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Cannabinoids: a new hope for breast cancer ... [Cancer Treat Rev. 2012] - PubMed - NCBI

Marijuana fights beast cancer, why wait for "officials" to approve it? Use it now! Family history of breast cancer? Use it now! History of poor diet and alcohol consumption? Use it now! Cancer Treat Rev. 2012 Nov;10. 2012

Cannabinoids: a new hope for breast cancer therapy?               Caffarel MM, et al., Dept. Biochemistry and Molecular Biology I, School of Biology, Complutense University-CIBERNED-IRYCIS, Madrid, Spain.                                                                                          Abstract: Breast cancer is a very common disease that affects approximately 1 in 10 women at some point in their lives. Importantly, breast cancer cannot be considered a single disease as it is characterized by distinct pathological and molecular subtypes that are treated with different therapies and have diverse clinical outcomes. Although some highly successful treatments have been developed, certain breast tumors are resistant to conventional therapies and a considerable number of them relapse. Therefore, new strategies are urgently needed, and the challenge for the future will most likely be the development of individualized therapies that specifically target each patient's tumor. Experimental evidence accumulated during the last decade supports that cannabinoids, the active components of Cannabis sativa and their derivatives, possess anticancer activity. Thus, these compounds exert anti-proliferative, pro-apoptotic, anti-migratory and anti-invasive actions in a wide spectrum of cancer cells in culture. Moreover, tumor growth, angiogenesis and metastasis are hampered by cannabinoids in xenograft-based and genetically-engineered mouse models of cancer. This review summarizes our current knowledge on the anti-tumor potential of cannabinoids in breast cancer, which suggests that cannabinoid-based medicines may be useful for the treatment of most breast tumor subtypes.Copyright © 2012 Elsevier Ltd. All rights reserved.

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Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

The non-psychoactive cannabinoid CBD has powerful anti-tumor effects without toxic side-effects! It is only available at medical marijuana dispensaries, in certain states with protections for cannabis-using patients. Hopefully the war on dispensaries will end in Obama's 2nd term because street dealers do not sell cannabis products that don't get you high. If someone you love has breast cancer or another serious cancer, get to a medical state and get some CBD marijuana, or better yet concentrate. And raise hell to your elected officials about how prohibition harms us all! It's time to humiliate the defenders of this immoral prohibition policy as enemies of public health and human decency. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

Sean D. McAllister, et al.

Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. Clearly, effective and nontoxic therapies are urgently required. Id-1, an inhibitor of basic helix-loop-helix transcription factors, has recently been shown to be a key regulator of the metastatic potential of breast and additional cancers. Using a mouse model, we previously determined that metastatic breast cancer cells became significantly less invasive in vitro and less metastatic in vivo when Id-1 was down-regulated by stable transduction with antisense Id-1. It is not possible at this point, however, to use antisense technology to reduce Id-1 expression in patients with metastatic breast cancer. Here, we report that cannabidiol CBD, a cannabinoid with a low-toxicity profile, could down-regulate Id-1 expression in aggressive human breast cancer cells. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. CBD was able to inhibit Id-1 expression at the mRNA and protein level in a concentration-dependent fashion. These effects seemed to occur as the result of an inhibition of the Id-1 gene at the promoter level. Importantly, CBD did not inhibit invasiveness in cells that ectopically expressed Id-1. In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness. [Mol Cancer Ther 2007;611:2921–7]

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Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

The non-psychoactive cannabinoid CBD has powerful anti-tumor effects without toxic side-effects! It is only available at medical marijuana dispensaries, in certain states with protections for cannabis-using patients. Hopefully the war on dispensaries will end in Obama's 2nd term because street dealers do not sell cannabis products that don't get you high. If someone you love has breast cancer or another serious cancer, get to a medical state and get some CBD marijuana, or better yet concentrate. And raise hell to your elected officials about how prohibition harms us all! It's time to humiliate the defenders of this immoral prohibition policy as enemies of public health and human decency. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

Sean D. McAllister, et al.

Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. Clearly, effective and nontoxic therapies are urgently required. Id-1, an inhibitor of basic helix-loop-helix transcription factors, has recently been shown to be a key regulator of the metastatic potential of breast and additional cancers. Using a mouse model, we previously determined that metastatic breast cancer cells became significantly less invasive in vitro and less metastatic in vivo when Id-1 was down-regulated by stable transduction with antisense Id-1. It is not possible at this point, however, to use antisense technology to reduce Id-1 expression in patients with metastatic breast cancer. Here, we report that cannabidiol CBD, a cannabinoid with a low-toxicity profile, could down-regulate Id-1 expression in aggressive human breast cancer cells. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. CBD was able to inhibit Id-1 expression at the mRNA and protein level in a concentration-dependent fashion. These effects seemed to occur as the result of an inhibition of the Id-1 gene at the promoter level. Importantly, CBD did not inhibit invasiveness in cells that ectopically expressed Id-1. In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness. [Mol Cancer Ther 2007;611:2921–7]

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Marijuana And Cancer: Scientists Find Cannabis Compound Stops Metastasis In Aggressive Cancers

Marijuana may be your best bet for beating cancer! A pair of scientists at California Pacific Medical Center in San Francisco has found that a compound derived from marijuana could stop metastasis in many kinds of aggressive cancer, potentially altering the fatality of the disease forever."It took us about 20 years of research to figure this out, but we are very excited," said Pierre Desprez, one of the scientists behind the discovery, to The Huffington Post. "We want to get started with trials as soon as possible."The San Francisco Chronicle first reported on the finding, which has already undergone both laboratory and animal testing, and is awaiting permission for clinical trials in humans.Desprez, a molecular biologist, spent decades studying ID-1, the gene that causes cancer to spread. Meanwhile, fellow researcher Sean McAllister was studying the effects of Cannabidiol, or CBD, a non-toxic, non-psychoactive chemical compound found in the cannabis plant. Finally, the pair collaborated, combining CBD and cells containing high levels of ID-1 in a petri dish."What we found was that his Cannabidiol could essentially 'turn off' the ID-1," Desprez told HuffPost. The cells stopped spreading and returned to normal."We likely would not have found this on our own," he added. "That's why collaboration is so essential to scientific discovery."Desprez and McAllister first published a paper about the finding in 2007. Since then, their team has found that CBD works both in the lab and in animals. And now, they've found even more good news."We started by researching breast cancer," said Desprez. "But now we've found that Cannabidiol works with many kinds of aggressive cancers--brain, prostate--any kind in which these high levels of ID-1 are present."

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