Marijuana use reduces alcohol and tobacco users' risk for developing head and neck cancer

Marijuana use protects tobacco smokers and alcohol drinkers from head and neck cancer! Legalization is on its way to the USA! A population-based case-control study of marijuana use and head and neck squamous cell carcinoma.Liang C, McClean MD, Marsit C, Christensen B, Peters E, Nelson HH, Kelsey KT.SourceDepartment of Community Health, Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI, USA.

Abstract: Cannabinoids, constituents of marijuana smoke, have been recognized to have potential antitumor properties. However, the epidemiologic evidence addressing the relationship between marijuana use and the induction of head and neck squamous cell carcinoma HNSCC is inconsistent and conflicting. Cases n = 434 were patients with incident HNSCC disease from nine medical facilities in the Greater Boston, MA area between December 1999 and December 2003. Controls n = 547 were frequency matched to cases on age +/-3 years, gender, and town of residence.  After adjusting for potential confounders including smoking and alcohol drinking, 10 to 20 years of marijuana use was associated with a significantly reduced risk of HNSCC [odds ratio OR10-<20 years versus never users, 0.38; 95% confidence interval CI, 0.22-0.67]. Among marijuana users moderate weekly use was associated with reduced risk OR0.5-<1.5 times versus <0.5 time, 0.52; 95% CI, 0.32-0.85. The magnitude of reduced risk was more pronounced for those who started use at an older age OR15-<20 years versus never users, 0.53; 95% CI, 0.30-0.95; OR> or =20 years versus never users, 0.39; 95% CI, 0.17-0.90; Ptrend < 0.001. These inverse associations did not depend on human papillomavirus 16 antibody status. However, for the subjects who have the same level of smoking or alcohol drinking, we observed attenuated risk of HNSCC among those who use marijuana compared with those who do not. Our study suggests that moderate marijuana use is associated with reduced risk of HNSCC.

Marijuana use reduces alcohol and tobacco users' risk for developing head and neck cancer

Marijuana use protects tobacco smokers and alcohol drinkers from head and neck cancer! Legalization is on its way to the USA! A population-based case-control study of marijuana use and head and neck squamous cell carcinoma.Liang C, McClean MD, Marsit C, Christensen B, Peters E, Nelson HH, Kelsey KT.SourceDepartment of Community Health, Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI, USA.

Abstract: Cannabinoids, constituents of marijuana smoke, have been recognized to have potential antitumor properties. However, the epidemiologic evidence addressing the relationship between marijuana use and the induction of head and neck squamous cell carcinoma HNSCC is inconsistent and conflicting. Cases n = 434 were patients with incident HNSCC disease from nine medical facilities in the Greater Boston, MA area between December 1999 and December 2003. Controls n = 547 were frequency matched to cases on age +/-3 years, gender, and town of residence.  After adjusting for potential confounders including smoking and alcohol drinking, 10 to 20 years of marijuana use was associated with a significantly reduced risk of HNSCC [odds ratio OR10-<20 years versus never users, 0.38; 95% confidence interval CI, 0.22-0.67]. Among marijuana users moderate weekly use was associated with reduced risk OR0.5-<1.5 times versus <0.5 time, 0.52; 95% CI, 0.32-0.85. The magnitude of reduced risk was more pronounced for those who started use at an older age OR15-<20 years versus never users, 0.53; 95% CI, 0.30-0.95; OR> or =20 years versus never users, 0.39; 95% CI, 0.17-0.90; Ptrend < 0.001. These inverse associations did not depend on human papillomavirus 16 antibody status. However, for the subjects who have the same level of smoking or alcohol drinking, we observed attenuated risk of HNSCC among those who use marijuana compared with those who do not. Our study suggests that moderate marijuana use is associated with reduced risk of HNSCC.

via A population-based case-control stud... [Cancer Prev Res Phila. 2009] - PubMed - NCBI.

Towards the use of cannabinoids as antitumour agents : Abstract : Nature Reviews Cancer

PerspectivesNature Reviews Cancer 12, 436-444 June 2012 | doi:10.1038/nrc3247                                                                      Opinion: Towards the use of cannabinoids as antitumour agents Guillermo Velasco1,2,3, Cristina Sánchez1 & Manuel Guzmán1,2,4 Various reports have shown that cannabinoids the active components of marijuana and their derivatives can reduce tumour growth and progression in animal models of cancer, in addition to their well-known palliative effects on some cancer-associated symptoms. This Opinion article discusses our current understanding of cannabinoids as antitumour agents, focusing on recent insights into the molecular mechanisms of action, including emerging resistance mechanisms and opportunities for combination therapy approaches. Such knowledge is required for the optimization of preclinical cannabinoid-based therapies and for the preliminary clinical testing that is currently underway.

via Towards the use of cannabinoids as antitumour agents : Abstract : Nature Reviews Cancer.