CBD from marijuana protects the brain from Alzheimer's disease and triggers the production of new brain cells

Like THC, the cannabinoid CBD from marijuana protects the brain from the damage that leads to Alzheimer's disease and other forms of dementia. CBD, which lacks the psychoactive effects of THC, is only available from cannabis products sold by dispensaries, dealers do not sell marijuana that doesn't get you high. Why are communities shortsightedly moving to close dispensaries? Reefer madness residue and marijuanaphobia. Speak out for medical marijuana! Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.       Esposito G, Scuderi C, Valenza M, Togna GI, Latina V, De Filippis D, Cipriano M, Carratù MR, Iuvone T, Steardo L.SourceDepartment of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, Rome, Italy.                                                                               Abstract: Peroxisome proliferator-activated receptor-γ PPARγ has been reported to be involved in the etiology of pathological features of Alzheimer's disease AD. Cannabidiol CBD, a Cannabis derivative devoid of psychomimetic effects, has attracted much attention because of its promising neuroprotective properties in rat AD models, even though the mechanism responsible for such actions remains unknown. This study was aimed at exploring whether CBD effects could be subordinate to its activity at PPARγ, which has been recently indicated as its putative binding site. CBD actions on β-amyloid-induced neurotoxicity in rat AD models, either in presence or absence of PPAR antagonists were investigated. Results showed that the blockade of PPARγ was able to significantly blunt CBD effects on reactive gliosis and subsequently on neuronal damage. Moreover, due to its interaction at PPARγ, CBD was observed to stimulate hippocampal neurogenesis. All these findings report the inescapable role of this receptor in mediating CBD actions, here reported.

via Cannabidiol reduces Aβ-induced neuroinflammation an... [PLoS One. 2011] - PubMed - NCBI.

Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI

CBD a plant cannabinoid found in marijuana/cannabis is a possible, effective treatment for Kaposi sarcoma. It's been about 16 years since effective anti-viral medicines were released for AIDS patients so many of you have never seen someone covered in and disfigured by purple KS lesions but anything that offers relief should be made available, not kept on Schedule one of the Controlled Substances Act. KS is not a disease that is exclusive to AIDS patients therefore CBD might benefit those who cannot use anti-retroviral drugs. Legalize the plant for goodness sake! Genes Cancer. 2012 Jul;37-8:512-20.

.Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.   Maor Y, Yu J, Kuzontkoski PM, Dezube BJ, Zhang X, Groopman JE.  SourceDivision of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Abstract: Kaposi sarcoma is the most common neoplasm caused by Kaposi sarcoma-associated herpesvirus KSHV. It is prevalent among the elderly in the Mediterranean, inhabitants of sub-Saharan Africa, and immunocompromised individuals such as organ transplant recipients and AIDS patients. Current treatments for Kaposi sarcoma can inhibit tumor growth but are not able to eliminate KSHV from the host. When the host's immune system weakens, KSHV begins to replicate again, and active tumor growth ensues. New therapeutic approaches are needed. Cannabidiol CBD, a plant-derived cannabinoid, exhibits promising antitumor effects without inducing psychoactive side effects. CBD is emerging as a novel therapeutic for various disorders, including cancer. In this study, we investigated the effects of CBD both on the infection of endothelial cells ECs by KSHV and on the growth and apoptosis of KSHV-infected ECs, an in vitro model for the transformation of normal endothelium to Kaposi sarcoma. While CBD did not affect the efficiency with which KSHV infected ECs, it reduced proliferation and induced apoptosis in those infected by the virus. CBD inhibited the expression of KSHV viral G protein-coupled receptor vGPCR, its agonist, the chemokine growth-regulated protein α GRO-α, vascular endothelial growth factor receptor 3 VEGFR-3, and the VEGFR-3 ligand, vascular endothelial growth factor C VEGF-C. This suggests a potential mechanism by which CBD exerts its effects on KSHV-infected endothelium and supports the further examination of CBD as a novel targeted agent for the treatment of Kaposi sarcoma.

via Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI.

Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI

CBD a plant cannabinoid found in marijuana/cannabis is a possible, effective treatment for Kaposi sarcoma. It's been about 16 years since effective anti-viral medicines were released for AIDS patients so many of you have never seen someone covered in and disfigured by purple KS lesions but anything that offers relief should be made available, not kept on Schedule one of the Controlled Substances Act. KS is not a disease that is exclusive to AIDS patients therefore CBD might benefit those who cannot use anti-retroviral drugs. Legalize the plant for goodness sake! Genes Cancer. 2012 Jul;37-8:512-20.

.Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.   Maor Y, Yu J, Kuzontkoski PM, Dezube BJ, Zhang X, Groopman JE.  SourceDivision of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Abstract: Kaposi sarcoma is the most common neoplasm caused by Kaposi sarcoma-associated herpesvirus KSHV. It is prevalent among the elderly in the Mediterranean, inhabitants of sub-Saharan Africa, and immunocompromised individuals such as organ transplant recipients and AIDS patients. Current treatments for Kaposi sarcoma can inhibit tumor growth but are not able to eliminate KSHV from the host. When the host's immune system weakens, KSHV begins to replicate again, and active tumor growth ensues. New therapeutic approaches are needed. Cannabidiol CBD, a plant-derived cannabinoid, exhibits promising antitumor effects without inducing psychoactive side effects. CBD is emerging as a novel therapeutic for various disorders, including cancer. In this study, we investigated the effects of CBD both on the infection of endothelial cells ECs by KSHV and on the growth and apoptosis of KSHV-infected ECs, an in vitro model for the transformation of normal endothelium to Kaposi sarcoma. While CBD did not affect the efficiency with which KSHV infected ECs, it reduced proliferation and induced apoptosis in those infected by the virus. CBD inhibited the expression of KSHV viral G protein-coupled receptor vGPCR, its agonist, the chemokine growth-regulated protein α GRO-α, vascular endothelial growth factor receptor 3 VEGFR-3, and the VEGFR-3 ligand, vascular endothelial growth factor C VEGF-C. This suggests a potential mechanism by which CBD exerts its effects on KSHV-infected endothelium and supports the further examination of CBD as a novel targeted agent for the treatment of Kaposi sarcoma.

via Cannabidiol inhibits growth and induces program... [Genes Cancer. 2012] - PubMed - NCBI.

Chemopreventive effect of the non-psychotro... [J Mol Med (Berl). 2012] - PubMed - NCBI

Chemoprevention of disease with cannabis--this is what everyone should be talking about. Using marijuana can protect you from serious illnesses by reducing inflammation, counteracting harmful oxidation, down regulating the production of harmful chemicals in the body, stimulating the production of beneficial chemicals in the body and triggering our intrinsic repair mechanisms, this is big news! We need to encourage everyone we meet to consider embracing cannabis supplementation to guard themselves from Alzheimer's disease, cancer, diabetes and more with chemoprevention.  

J Mol Med (Berl). 2012 Aug;90(8):925-34. Epub 2012 Jan 10.

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

Aviello G, Romano B, Borrelli F, Capasso R, Gallo L, Piscitelli F, Di Marzo V, Izzo AA.

Source

Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy.

Abstract

Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms.

PMID:

22231745

[PubMed - in process]

via Chemopreventive effect of the non-psychotro... [J Mol Med (Berl). 2012] - PubMed - NCBI.