THC from marijuana is an anticancer drug

How long will this government-perpetrated fraud that there is no such thing as medical marijuana endure in the face of an overwhelming tsunami of science which proves that marijuana delivers health-building and protecting cannabinoids which fight disease and enhance our vitality? Promote adult marijuana use! From the following report, "THC has shown therapeutic potential as an anticancer drug." J Drug Target. 2013 Jun 18. [Epub ahead of print]

Preparation and characterization of Δ9-tetrahydrocannabinol-loaded biodegradable polymeric microparticles and their antitumoral efficacy on cancer cell lines.

de la Ossa DH, Gil-Alegre ME, Ligresti A, Aberturas MD, Molpeceres J, Torres AI, Di Marzo V.

Source

Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Complutense University of Madrid , Madrid , Spain .

Abstract

Abstract: Cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases (cancer, AIDS and multiple sclerosis), analgesics, and in the treatment of multiple sclerosis and cancer, among other conditions. However, despite their high clinical potential, only few dosage forms are available to date. In this paper, the development of Δ9-tetrahydrocannabinol (THC) biodegradable microspheres as an alternative delivery system for cannabinoid parenteral administration is proposed. Tetrahydrocannabinol was encapsulated into biodegradable microspheres by the oil-in-water (o/w) emulsion solvent evaporation method. Several formulations were prepared using different drug:polymer ratios. The influence of antioxidant (α-tocopherol acetate) concentration on the release of THC from the microparticles was studied. Elevated process yield and entrapment efficiencies were achieved. The in vitro drug release studies showed that the encapsulated drug was released over a two week period. As THC has shown therapeutic potential as anticancer drug, the efficacy of the microspheres was tested on different cancer cell lines. Interestingly, the microspheres were able to inhibit cancer cell proliferation during the nine-day study period. All the above results suggest that the use of biodegradable microspheres would be a suitable alternative delivery system for THC administration.

via Preparation and characterization of Δ9-tetrahy... [J Drug Target. 2013] - PubMed - NCBI.

Cannabinoids may be therapeutic in breast c... [Oncol Nurs Forum. 2013] - PubMed - NCBI

I know it is hard for some of you to believe, but marijuana is the anti-cancer plant, science has spoken! Oncol Nurs Forum. 2013 Mar 1;402:191-2. doi: 10.1188/13.ONF.191-192

Cannabinoids may be therapeutic in breast cancer                .Behrend SW.SourceDepartment of Nursing, Fox Chase Cancer Center, Philadelphia, PA.                                                           Abstract:Cannabinoids are a group of compounds synthesized exclusively by the Cannabis sativa plant, commonly known as marijuana. In 1990, the first cannabinoid-specific membrane CB1 was characterized and cloned Matsuda, Lolait, Brownstein, Young, & Bonner, 1990, which catapulted biomedical research on these unique compounds. Cannabinoids refer to both marijuana-derived compounds with the active ingredient of 9-tetrahydrocannabinol THC and also the synthetic molecules that activate the same primary targets as THC. Therapeutic properties of marijuana have been well established; however, the clinical use of either plant-sourced or pure cannabinoids remains limited. The anticachexia properties of cannabinoids are found in tetrahydrocannabinol oral capsules of synthetically generated THC and are used to manage weight loss, wasting syndrome, and nausea and vomiting associated with cancer treatment.PMID: 23448745 [PubMed - in process]

via Cannabinoids may be therapeutic in breast c... [Oncol Nurs Forum. 2013] - PubMed - NCBI.

Use of cannabinoid rece... [Best Pract Res Clin Endocrinol Metab. 2009] - PubMed - NCBI

THC from marijuana is a safe, effective and thoroughly enjoyable cannabinoid receptor agonist. Best Pract Res Clin Endocrinol Metab. 2009 Feb;                                                                                                      Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents.                                            Pisanti S, Malfitano AM, Grimaldi C, Santoro A, Gazzerro P, Laezza C, Bifulco M.Source Department of Pharmaceutical Sciences, University of Salerno, Italy.                                                                                           Abstract: Cannabinoids the active components of Cannabis sativa and their derivatives have received renewed interest in recent years due to their diverse pharmacological activities. In particular, cannabinoids offer potential applications as anti-tumour drugs, based on the ability of some members of this class of compounds to limit cell proliferation and to induce tumour-selective cell death. Although synthetic cannabinoids may have pro-tumour effects in vivo due to their immunosuppressive properties, predominantly inhibitory effects on tumour growth and migration, angiogenesis, metastasis, and also inflammation have been described. Emerging evidence suggests that agonists of cannabinoid receptors expressed by tumour cells may offer a novel strategy to treat cancer. In this chapter we review the more recent results generating interest in the field of cannabinoids and cancer, and provide novel suggestions for the development, exploration and use of cannabinoid agonists for cancer therapy, not only as palliative but also as curative drugs.PMID: 19285265 [PubMed - indexed for MEDLINE]

via Use of cannabinoid rece... [Best Pract Res Clin Endocrinol Metab. 2009] - PubMed - NCBI.

Cannabinoids induce apoptosis of pancreatic tumor... [Cancer Res. 2006] - PubMed - NCBI

Cancer Res. 2006 Jul 1;6613:6748-55.Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.Carracedo A, Gironella M, Lorente M, Garcia S, Guzmán M, Velasco G, Iovanna JL.SourceDepartment of Biochemistry and Molecular Biology I, School of Biology, Complutense University, c/José Antonio Novais s/n, 28040 Madrid, Spain                                                                                   .     Abstract: Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore, it is of especial interest to set new strategies aimed at improving the prognostic of this deadly disease. The present study was undertaken to investigate the action of cannabinoids, a new family of potential antitumoral agents, in pancreatic cancer. We show that cannabinoid receptors are expressed in human pancreatic tumor cell lines and tumor biopsies at much higher levels than in normal pancreatic tissue. Studies conducted with MiaPaCa2 and Panc1 cell lines showed that cannabinoid administration a induced apoptosis, b increased ceramide levels, and c up-regulated mRNA levels of the stress protein p8. These effects were prevented by blockade of the CB2 cannabinoid receptor or by pharmacologic inhibition of ceramide synthesis de novo. Knockdown experiments using selective small interfering RNAs showed the involvement of p8 via its downstream endoplasmic reticulum stress-related targets activating transcription factor 4 ATF-4 and TRB3 in Delta9-tetrahydrocannabinol-induced apoptosis. Cannabinoids also reduced the growth of tumor cells in two animal models of pancreatic cancer. In addition, cannabinoid treatment inhibited the spreading of pancreatic tumor cells. Moreover, cannabinoid administration selectively increased apoptosis and TRB3 expression in pancreatic tumor cells but not in normal tissue. In conclusion, results presented here show that cannabinoids lead to apoptosis of pancreatic tumor cells via a CB2 receptor and de novo synthesized ceramide-dependent up-regulation of p8 and the endoplasmic reticulum stress-related genes ATF-4 and TRB3. These findings may contribute to set the basis for a new therapeutic approach for the treatment of pancreatic cancer. via Cannabinoids induce apoptosis of pancreatic tumor... [Cancer Res. 2006] - PubMed - NCBI.