Marijuana Use Reduces Obesity » Marijuana Gateway to Health

Marijuana use is significantly protective against obesity as well as the harmful illnesses that accompany the syndrome. This is because THC and other cannabinoids work as systemic biological health regulators, the are key to our ability to survive and thrive. We really do need to encourage more adults to use marijuana in some form to improve their health and guard against degenerative illnesses. Science continues to affirm this position.                       Med Hypotheses. 2013 Feb 11. Cannabis and Δ9-tetrahydrocannabinol THC for weight loss?Le Foll B, Trigo JM, et al.Abstract: Obesity is one of the highest preventable causes of morbidity and mortality in the developed world [1]. It has been well known for a long time that exposure to cannabis produces an increase of appetite a phenomenon referred to as the ‘munchies’. This phenomenon led to an exploration of the role of the endocannabinoid system in the regulation of obesity and associated metabolic syndrome. This effort subsequently led to the development of a successful therapeutic approach for obesity that consisted of blocking the cannabinoid CB1 receptors using ligands such as Rimonabant in order to produce weight loss and improve metabolic profile [2]. Despite being efficacious, Rimonabant was associated with increased rates of depression and anxiety and therefore removed from the market. We recently discovered that the prevalence of obesity is paradoxically much lower in cannabis users as compared to non-users and that this difference is not accounted for by tobacco smoking status and is still present after adjusting for variables such as sex and age. Here, we propose that this effect is directly related to exposure to the Δ9-tetrahydrocannabinol THC present in cannabis smoke. We therefore propose the seemingly paradoxical hypothesis that THC or a THC/cannabidiol combination drug may produce weight loss and may be a useful therapeutic for the treatment of obesity and its complications.via Cannabis and Δ9-tetrahydrocannabinol THC … [Med Hypotheses. 2013] – PubMed – NCBI. via Marijuana Use Reduces Obesity » Marijuana Gateway to Health.

Marijuana use fights diabetes and lowers waist fat

The irrational opponents of marijuana legalization are having a harder and harder time of making the case that using it is harmful when we see that marijuana smokers suffer from less obesity and have significant protection from developing diabetes. Therefore, encouraging adult use of marijuana will work to lower our national health-care costs. Am J Med. 2013 May 9. The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults. Penner EA, Buettner H, Mittleman MA.SourceUniversity of Nebraska College of Medicine, Omaha; Department of Epidemiology, Harvard School of Public Health, Boston, Mass.AbstractBACKGROUND:There are limited data regarding the relationship between cannabinoids and metabolic processes. Epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared with people who have never used marijuana, suggesting a relationship between cannabinoids and peripheral metabolic processes. To date, no study has investigated the relationship between marijuana use and fasting insulin, glucose, and insulin resistance.METHODS:We included 4657 adult men and women from the National Health and Nutrition Examination Survey from 2005 to 2010. Marijuana use was assessed by self-report in a private room. Fasting insulin and glucose were measured via blood samples after a 9-hour fast, and homeostasis model assessment of insulin resistance HOMA-IR was calculated to evaluate insulin resistance. Associations were estimated using multiple linear regression, accounting for survey design and adjusting for potential confounders.RESULTS:Of the participants in our study sample, 579 were current marijuana users and 1975 were past users. In multivariable adjusted models, current marijuana use was associated with 16% lower fasting insulin levels 95% confidence interval [CI], -26, -6 and 17% lower HOMA-IR 95% CI, -27, -6. We found significant associations between marijuana use and smaller waist circumferences. Among current users, we found no significant dose-response.CONCLUSIONS:We found that marijuana use was associated with lower levels of fasting insulin and HOMA-IR, and smaller waist circumference.

via The Impact of Marijuana Use on Glucose, Insulin, an... [Am J Med. 2013] - PubMed - NCBI.

The relationships between sugar-sweetened b... [J Acad Nutr Diet. 2013] - PubMed - NCBI

Sugar creates pro-disease environments and effects. Why don't the prohibitionists work against the "Big Sugar" industry that is addicting kids into seriously self-destructive life-styles? Although teens should not use marijuana, it is interesting that using the plant regularly reduces obesity and the incidence of diabetes. Maybe obese teens could benefit from a marijuana pill that has less THC than CBD and is therefore not psychoactive. J Acad Nutr Diet. 2013 Feb                                                              The relationships between sugar-sweetened beverage intake and cardiometabolic markers in young children.                               Kosova EC, Auinger P, Bremer AA.SourceDepartment of Medicine, Brigham and Women’s Hospital, Boston, MA, USA.               Abstract: BACKGROUND:The consumption of sugar-sweetened beverages has been implicated as a major contributor to the development of obesity and cardiometabolic disease.OBJECTIVE:To evaluate the relationships between sugar-sweetened beverage intake and cardiometabolic markers in young children.DESIGN:A cross-sectional analysis of the National Health and Nutrition Examination Survey data collected by the National Center for Health Statistics.PARTICIPANTS:A total of 4,880 individuals aged 3 to 11 years from nationally representative samples of US children participating in the National Health and Nutrition Examination Survey during 1999-2004 were studied.MAIN OUTCOME MEASURES:Concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, and C-reactive protein as well as waist circumference and body mass index percentile for age-sex.STATISTICAL ANALYSES PERFORMED:Multivariate linear regression analyses were performed to determine independent associations between each outcome variable and the number of serving equivalents of sugar-sweetened beverages consumed after adjusting for age, sex, race, poverty status, physical activity, and energy intake.RESULTS:Increased sugar-sweetened beverage intake was independently associated with increased C-reactive protein concentrations P=0.003, increased waist circumference P=0.04, and decreased high-density lipoprotein cholesterol concentrations P<0.001. Subgroup analyses demonstrated differences in the association of sugar-sweetened beverage intake with metabolic markers and anthropometric measurements among age ranges, sex, and racial/ethnic groups.CONCLUSIONS:In this cross-sectional analysis of children's dietary data, sugar-sweetened beverage intake was independently associated with alterations in lipid profiles, increased markers of inflammation, and increased waist circumference in children. Prospective studies are needed, but awareness of these trends is essential in combating the growing metabolic and cardiovascular disease burden in the pediatric population.Copyright © 2013 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.PMID: 23351625 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, Substances, Grant Support

via The relationships between sugar-sweetened b... [J Acad Nutr Diet. 2013] - PubMed - NCBI.

Obesity and cannabis use: results from 2 repr... [Am J Epidemiol. 2011] - PubMed - NCBI

Smoking marijuana significantly protects users from obesity and related diseases. Tell someone today! Am J Epidemiol. 2011 Oct 15;1748:929-33.  2011 Aug 24.

Obesity and cannabis use: results from 2 representative national surveys.                                                                                              Le Strat Y, Le Foll B.SourceTranslational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.                                                                                   Abstract: The role of cannabis and endocannabinoids in appetite regulation has been extensively studied, but the association of cannabis use with weight in the general population is not known. The authors used data from 2 representative epidemiologic studies of US adults aged 18 years or older, the National Epidemiologic Survey on Alcohol and Related Conditions NESARC; 2001-2002 and the National Comorbidity Survey-Replication NCS-R; 2001-2003, to estimate the prevalence of obesity as a function of cannabis use. The adjusted prevalences of obesity in the NESARC and the NCS-R were 22.0% and 25.3%, respectively, among participants reporting no use of cannabis in the past 12 months and 14.3% and 17.2%, respectively, among participants reporting the use of cannabis at least 3 days per week. These differences were not accounted for by tobacco smoking status. Additionally, after adjustment for sex and age, the use of cannabis was associated with body mass index differences in both samples. The authors conclude that the prevalence of obesity is lower in cannabis users than in nonusers.

via Obesity and cannabis use: results from 2 repr... [Am J Epidemiol. 2011] - PubMed - NCBI.

Cannabis exposure associated with weight reduc... [Phytomedicine. 2012] - PubMed - NCBI

Marijuana use protects us from developing diabetes by reducing obesity and protecting pancreatic insulin-producing cells from its damaging effects. A large population study has confirmed a significant reduction in diabetes among regular marijuana smokers. Cannabis exposure associated with weight reduction and β-cell protection in an obese rat model.Levendal RA, Schumann D, Donath M, Frost CL.SourceDepartment of Biochemistry and Microbiology, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa.

Abstract: The aim of this study was to investigate the effect of an organic cannabis extract on β-cell secretory function in an in vivo diet-induced obese rat model and determine the associated molecular changes within pancreatic tissue. Diet-induced obese Wistar rats and rats fed on standard pellets were subcutaneously injected with an organic cannabis extract or the vehicle over a 28-day period. The effect of diet and treatment was evaluated using the intraperitoneal glucose tolerance tests IPGTTs and qPCR analysis on rat pancreata harvested upon termination of the experiment. The cafeteria diet induced an average weight difference of 32g and an overall increase in body weight in the experimental groups occurred at a significantly slower rate than the control groups, irrespective of diet. Area under the curve for glucose AUCg in the obese group was significantly lower compared to the lean group p<0.001, with cannabis treatment significantly reducing the AUCg in the lean group p<0.05, and remained unchanged in the obese group, relative to the obese control group. qPCR analysis showed that the cafeteria diet induced down-regulation of the following genes in the obese control group, relative to lean controls: UCP2, c-MYC and FLIP. Cannabis treatment in the obese group resulted in up-regulation of CB1, GLUT2, UCP2 and PKB, relative to the obese control group, while c-MYC levels were down-regulated, relative to the lean control group. Treatment did not significantly change gene expression in the lean group. These results suggest that the cannabis extract protects pancreatic islets against the negative effects of obesity.

via Cannabis exposure associated with weight reduc... [Phytomedicine. 2012] - PubMed - NCBI.

Chemopreventive effect of the non-psychotro... [J Mol Med (Berl). 2012] - PubMed - NCBI

Chemoprevention of disease with cannabis--this is what everyone should be talking about. Using marijuana can protect you from serious illnesses by reducing inflammation, counteracting harmful oxidation, down regulating the production of harmful chemicals in the body, stimulating the production of beneficial chemicals in the body and triggering our intrinsic repair mechanisms, this is big news! We need to encourage everyone we meet to consider embracing cannabis supplementation to guard themselves from Alzheimer's disease, cancer, diabetes and more with chemoprevention.  

J Mol Med (Berl). 2012 Aug;90(8):925-34. Epub 2012 Jan 10.

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

Aviello G, Romano B, Borrelli F, Capasso R, Gallo L, Piscitelli F, Di Marzo V, Izzo AA.


Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy.


Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms.



[PubMed - in process]

via Chemopreventive effect of the non-psychotro... [J Mol Med (Berl). 2012] - PubMed - NCBI.