Acute Δ9-tetrahydrocannabinol blocks gastric... [Eur J Pharmacol. 2013] - PubMed - NCBI

THC blocks stomach damage from NSAIDs (nonsteroidal anti-inflammatory drugs) with doses that do not cause mind-altering effects. Marijuana, it's not just about getting high anymore!. Eur J Pharmacol. 2013 Jun 11. pii: S0014-29991300461-5. doi: 10.1016/j.ejphar.2013.06.001. [Epub ahead of print]Acute Δ9-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice.Kinsey SG, Cole EC.SourceDepartment of Psychology, West Virginia University, Morgantown, WV USA. Electronic address: sgkinsey@mail.wvu.edu.AbstractNonsteroidal anti-inflammatory drugs NSAIDs, which are among the most widely used analgesics in the world, cause gastrointestinal inflammation that is potentially life-threatening. Although inhibitors of endocannabinoid catabolic enzymes protect against gastropathy in fasted NSAID-treated mice, the gastroprotective effects of Δ9-tetrahydrocannabinol THC, the primary psychoactive component of marijuana, have yet to be investigated. Male C57BL/6J mice were fasted, administered vehicle or Δ9-THC .01-50mg/kg; oral or intraperitoneal, and then treated with the NSAID diclofenac sodium 100mg/kg, p.o. to induce gastric lesions. In separate groups of mice, the cannabimimetic behavioral effects of Δ9-THC given via each route of administration were compared using a battery of tests, consisting of assessment of locomotor activity, nociception in the tail withdrawal test, catalepsy in the bar test, and hypothermia. Δ9-THC dose-dependently attenuated diclofenac-induced gastric hemorrhagic streaks through both p.o. and i.p. routes of administration ED50 95% confidence interval=0.64 0.26-1.55 mg/kg and 0.06 0.01-0.34 mg/kg, respectively. Δ9-THC given i.p. was 2-3 orders of magnitude more potent in reducing diclofenac-induced gastric ulcers than in producing locomotor immobility, antinociception, hypothermia, and catalepsy, while the potency of ratio of p.o. Δ9-THC between each behavior measure was 7-18. These data indicate that the phytocannabinoid Δ9-THC protects against diclofenac-induced gastric inflammatory tissue damage at doses insufficient to cause common cannabinoid side effects.

via Acute Δ9-tetrahydrocannabinol blocks gastric... [Eur J Pharmacol. 2013] - PubMed - NCBI.

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Acute Δ9-tetrahydrocannabinol blocks gastric... [Eur J Pharmacol. 2013] - PubMed - NCBI

THC blocks stomach damage from NSAIDs (nonsteroidal anti-inflammatory drugs) with doses that do not cause mind-altering effects. Marijuana, it's not just about getting high anymore!. Eur J Pharmacol. 2013 Jun 11. pii: S0014-29991300461-5. doi: 10.1016/j.ejphar.2013.06.001. [Epub ahead of print]Acute Δ9-tetrahydrocannabinol blocks gastric hemorrhages induced by the nonsteroidal anti-inflammatory drug diclofenac sodium in mice.Kinsey SG, Cole EC.SourceDepartment of Psychology, West Virginia University, Morgantown, WV USA. Electronic address: sgkinsey@mail.wvu.edu.AbstractNonsteroidal anti-inflammatory drugs NSAIDs, which are among the most widely used analgesics in the world, cause gastrointestinal inflammation that is potentially life-threatening. Although inhibitors of endocannabinoid catabolic enzymes protect against gastropathy in fasted NSAID-treated mice, the gastroprotective effects of Δ9-tetrahydrocannabinol THC, the primary psychoactive component of marijuana, have yet to be investigated. Male C57BL/6J mice were fasted, administered vehicle or Δ9-THC .01-50mg/kg; oral or intraperitoneal, and then treated with the NSAID diclofenac sodium 100mg/kg, p.o. to induce gastric lesions. In separate groups of mice, the cannabimimetic behavioral effects of Δ9-THC given via each route of administration were compared using a battery of tests, consisting of assessment of locomotor activity, nociception in the tail withdrawal test, catalepsy in the bar test, and hypothermia. Δ9-THC dose-dependently attenuated diclofenac-induced gastric hemorrhagic streaks through both p.o. and i.p. routes of administration ED50 95% confidence interval=0.64 0.26-1.55 mg/kg and 0.06 0.01-0.34 mg/kg, respectively. Δ9-THC given i.p. was 2-3 orders of magnitude more potent in reducing diclofenac-induced gastric ulcers than in producing locomotor immobility, antinociception, hypothermia, and catalepsy, while the potency of ratio of p.o. Δ9-THC between each behavior measure was 7-18. These data indicate that the phytocannabinoid Δ9-THC protects against diclofenac-induced gastric inflammatory tissue damage at doses insufficient to cause common cannabinoid side effects.

via Acute Δ9-tetrahydrocannabinol blocks gastric... [Eur J Pharmacol. 2013] - PubMed - NCBI.