Low dose oral cannabinoid therapy reduces progression... [Nature. 2005] - PubMed - NCBI

It looks like regularly ingesting small amounts of THC can protect us from developing atherosclerosis, heart disease, by reducing inflammation. As more and more research is conducted on a broad range of illnesses, it is becoming more and more apparent that cannabinoids such as THC and CBD work as health modulating tonics for our bodies--reducing inflammation, decreasing levels of harmful chemicals that wreck destruction at the cellular and genetic levels and shielding cells from damaging influences from outside of the body. It really seems that almost everyone could benefit from taking a few drops of cannabis extract in the form of a tincture just before bedtime. It is stunning that these compounds have healing effects on everything from diabetes to heart disease to cancer to depression. Prohibition harms us all by making these health-building products unavailable to the general public and by ruining lives to maintain this fraudulent cruelty. Nature. 2005 Apr 7;4347034:782-6.

Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice.

Steffens S, et al.

Abstract: Atherosclerosis is a chronic inflammatory disease, and is the primary cause of heart disease and stroke in Western countries. Derivatives of cannabinoids such as delta-9-tetrahydrocannabinol THC modulate immune functions and therefore have potential for the treatment of inflammatory diseases. We investigated the effects of THC in a murine model of established atherosclerosis. Oral administration of THC 1 mg kg-1 per day resulted in significant inhibition of disease progression. This effective dose is lower than the dose usually associated with psychotropic effects of THC. Furthermore, we detected the CB2 receptor the main cannabinoid receptor expressed on immune cells in both human and mouse atherosclerotic plaques. Lymphoid cells isolated from THC-treated mice showed diminished proliferation capacity and decreased interferon-gamma secretion. Macrophage chemotaxis, which is a crucial step for the development of atherosclerosis, was also inhibited in vitro by THC. All these effects were completely blocked by a specific CB2 receptor antagonist. Our data demonstrate that oral treatment with a low dose of THC inhibits atherosclerosis progression in the apolipoprotein E knockout mouse model, through pleiotropic immunomodulatory effects on lymphoid and myeloid cells. Thus, THC or cannabinoids with activity at the CB2 receptor may be valuable targets for treating atherosclerosis.

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